Effect of Piroxicam on ART Outcome: A Pilot Study
نویسندگان
چکیده
BACKGROUND One of the most important factors affecting success rates in assisted reproductive techniques (ART) besides the number of oocytes retrieved and high quality embryos derived from them is the technical aspects of embryo transfer. It seems that pretreatement with uterine relaxants can be helpful in preventing un- pleasant cramps which can have an adverse effect on ART outcome. In this respect, some drugs such as prostaglandin inhibitors or sedatives have been evaluated but not confirmed yet remain controversial. This study was performed in order to assess the effect of administrating Piroxicam prior to embryo transfer on pregnancy rates in ART cycles. MATERIALS AND METHODS This pilot study was performed from August 2010 through December 2011 on 50 infertile women in ART cycles. Recombinant follicle stimulating hormone (rFSH) with a long gonadotropin releasing hormone (GnRH) analogue protocol were used for controlled ovarian hyperstimulation. The subjects were randomly allocated into two groups of 25 patients after obtaining written consent. Group A received a 10 mg Piroxicam capsule 30 minutes before embryo transfer and group B was the control group with no treatment. Data were analyzed by Chi-square and analysis of variance (ANOVA). RESULTS Pregnancy rate was 34% (n=17) totally, with 32% (n=8) in group A and 36% (n=9) in group B (p=0.75). Uterine cramps were experienced by 4 women (16%) in group B, while none were reported by women in group A (p=0.037). CONCLUSION It seems that Piroxicam administration 30 minutes prior to embryo transfer can- not increase pregnancy rates, but can prevent or reduce uterine cramps after the procedure.
منابع مشابه
An Investigation into the Effect of Various Penetration Enhancers on Percutaneous Absorption of Piroxicam
Achieving a desirable percutaneous absorption of drug molecule is a major concern in formulating dermatological products. The use of penetration enhancers could provide a successful mean for this purpose. The aim of this study was to evaluate the effect of incorporating a few common penetration enhancers (in different concentrations) into a 0.5% w/w piroxicam (model drug) gel formulation, on th...
متن کاملEffect of Melatonin on the Outcome of Assisted Reproductive Technique Cycles in Women with Diminished Ovarian Reserve: A Double-Blinded Randomized Clinical Trial
Diminished ovarian reserve (DOR) significantly decreases the success rate of the assisted reproductive technique (ART). In this study, we assessed the effect of melatonin on the ART outcomes in women with DOR. A double-blinded, randomized, clinical trial was performed on 80 women with DOR as a pilot study in Shiraz, between 2014 and 2015. DOR was defined as the presence of 2 of the following 3 ...
متن کاملP-189: Effect of Piroxicam Administration on Pregnancy Rate in Intrauterine Insemination (IUI) Cycles: A Randomized Clinical Trial
Background: To investigate the effect of administering piroxicam on improving the success rate of IUI cycles in those suffering from unexplained infertility. Materials and Methods: This was a randomized clinical trial being performed at Ghadir Mother and Child Hospital and Motahari clinics of Shiraz University of Medical Sciences. We included 260 women with unexplained infertility selected for ...
متن کاملInfluence of Dimethyl Sulfoxide as a Penetration Enhancer of Piroxicam Gel Through Biological Skin
Piroxicam is a non-steroidal anti-inflammatory agent which has an extensive use in rheumatic disorders. Since its skin penetration is still a subject for research, the aim of this study was to evaluate the effect of dimethyl sulfoxide on percutaneous penetration of piroxicam gel formulation through skin. In this study, as a model, two types of 0.5% piroxicam new gels, so called red and gr...
متن کامل